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N -Isocyaniminotriphenylphosphorane (Ph3PNNC) as an Efficient Reagent for the Synthesis of Fully Substituted 1,3,4-Oxadiazoles from 3-Phenyl-2-Propynoic Acid, Secondary Amines and Aromatic Bis-Aldehydes.
- Source :
-
Phosphorus, Sulfur & Silicon & the Related Elements . Jul2013, Vol. 188 Issue 7, p886-894. 9p. - Publication Year :
- 2013
-
Abstract
- Reactions of N-isocyaniminotriphenylphosphorane (Ph3PNNC) with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of 3-phenyl-2-propynoic acid and secondary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10426507
- Volume :
- 188
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Phosphorus, Sulfur & Silicon & the Related Elements
- Publication Type :
- Academic Journal
- Accession number :
- 89026954
- Full Text :
- https://doi.org/10.1080/10426507.2012.717142