P158 - SUPEROXIDE DISMUTASE 1 (CU/ZNSOD) POLYMORPHISMS IN TURKISH POPULATION.

Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide [1]. They play an important role in antioxidant mechanism in nearly all cells exposed to oxygen. Three isoforms of SOD are expressed in humans, encoded by different genes. SOD1 (CuZn-SOD) is mainly located in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. SOD1 accounts for ~ 85% of the total cellular SOD activity of most mammalian cells [2]. Genetic polymorphisms in SOD have been implicated in proneness to cancer and other diseases. These potentially significant genetic variants related to oxidative stress have already been studied extensively, including single nucleotide polymorphisms (SNP) -251A/G (rs2070424) of the SOD1 gene[3,4]. In the present study, the distribution of SOD1 gene -251A/G polymorphisms in a Turkish population including 494 (females: 278, 56,3% and males: 216, 43,7%) unrelated healthy individuals was examined using a PCRRFLP method. All genotypes and alleles were in Hardy-Weinberg equilibrium (X2=0,107, p>0.05). The mean age of the study population was 38,4±16,6 years (males, 39,8±17,1; females, 37,3±16,1). The frequency distributions of A and G alleles were found to be respectively 0,93 and 0,07. The observed genotype frequencies of SOD1 were 86.2, 13.4 and 0.4 % for AA, AG and GG, respectively. [ABSTRACT FROM AUTHOR]