Far-infrared radiation acutely increases nitric oxide production by increasing Ca2+ mobilization and Ca2+/calmodulin-dependent protein kinase II-mediated phosphorylation of endothelial nitric oxide synthase at serine 1179.

Highlights: [•] Far-infrared (FIR) radiation increases eNOS-Ser1179 phosphorylation and NO production in BAEC. [•] CaMKII and PKA mediate FIR-stimulated increases in eNOS-Ser1179 phosphorylation. [•] FIR increases intracellular Ca2+ levels. [•] Thermo-sensitive TRPV Ca2+ channels are unlikely to be involved in the FIR-mediated eNOS-Ser1179 phosphorylation pathway. [ABSTRACT FROM AUTHOR]