Human xylosyltransferase-I – A new marker for myofibroblast differentiation in skin fibrosis.

Authors :: Faust, I.
Roch, C.
Kuhn, J.
Prante, C.
Knabbe, C.
Hendig, D.
Source :: Biochemical & Biophysical Research Communications. Jul2013, Vol. 436 Issue 3, p449-454. 6p.
Publication Year :: 2013
Abstract: Highlights: [•] Xylosyltransferase-I (XT-I) was investigated as a biomarker in skin fibrosis. [•] Myofibroblast differentiation was followed by an increased XYLT1 mRNA expression. [•] XT activity increased in response to progressive myofibroblast transformation. [•] XT-I is a biomarker useful for depicting manifested skin fibrosis and its development. [ABSTRACT FROM AUTHOR]

Subjects :: *TRANSFERASES
*MYOFIBROBLASTS
*CELL differentiation
*FIBROSIS
*BIOMARKERS
*MESSENGER RNA
*GENE expression

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