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Thrombin-sensitive expression of the store operated Ca2+ channel Orai1 in platelets.
- Source :
-
Biochemical & Biophysical Research Communications . Jun2013, Vol. 436 Issue 1, p25-30. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] In blood platelets, thrombin upregulates protein abundance of Ca2+ channel Orai1. [•] The effect is paralleled by transient formation of mRNA from pre-RNA. [•] The effect is blunted by inhibition of translation but not by inhibition of transcription. [•] The effect is blunted by pharmacological inhibition of phosphoinositide-3-kinase. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 436
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 88987522
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.05.031