Thrombin-sensitive expression of the store operated Ca2+ channel Orai1 in platelets.

Highlights: [•] In blood platelets, thrombin upregulates protein abundance of Ca2+ channel Orai1. [•] The effect is paralleled by transient formation of mRNA from pre-RNA. [•] The effect is blunted by inhibition of translation but not by inhibition of transcription. [•] The effect is blunted by pharmacological inhibition of phosphoinositide-3-kinase. [ABSTRACT FROM AUTHOR]