Principal role of IL-12p40 in the decreased Th1 and Th17 responses driven by dendritic cells of mice lacking IL-12 and IL-18.

Highlights: [•] Dendritic cells (DCs) of mice lacking IL-12p40 and/or IL-18 were compared. [•] Deficiency of IL-12p40 and/or IL-18 in DCs showed similar surface phenotypes. [•] IL-12p40/IL-18-deficient DCs showed decreased IL-10 production. [•] IL-12p40- and IL-12p40/IL-18-deficient DCs impaired Th1 and Th17 differentiation. [•] IL-12p40 is more crucial than IL-18 in inducing Th1 and Th17 differentiation. [ABSTRACT FROM AUTHOR]