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An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.
- Source :
-
Biochemical & Biophysical Research Communications . Apr2013, Vol. 433 Issue 4, p390-395. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] The E3 ubiquitin-ligases SIAH1 and SIAH2 are interacting partners of USP19. [•] SIAH1 and SIAH2 promote USP19 ubiquitylation and degradation by the proteasome. [•] The interaction is mediated by a conserved SIAH-specific degron in USP19. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 433
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 88980761
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.02.094