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MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
- Source :
-
British Journal of Cancer . 11/1/2000, Vol. 83 Issue 9, p1192. 10p. - Publication Year :
- 2000
-
Abstract
- Qualitative differences in the MHC class II antigen processing and presentation pathway may be instrumental in shaping the CD4+ T cell response directed against tumour cells. Efficient loading of many MHC class II alleles with peptides requires the assistance of H2-M, a heterodimeric MHC class II-like molecule. In contrast to the HLA-DM region in humans, the β-chain locus is duplicated in mouse, with the H2-Mb1 (Mb1β-chain distal to H2-Mb2 (Mb2) and the H2-Ma (Ma) α-chain gene). Here, we show that murine MHC class II and H2-M genes are coordinately regulated in murine tumour cell lines by T helper cell 1 (IFN-γ) and T helper cell 2 (IL-4 or IL-10) cytokines in the presence of the MHC class II-specific transactivator CIITA as determined by mRNA expression and Western blot analysis. Furthermore, Mαβ1 and Mαβ2 heterodimers are differentially expressed in murine tumour cell lines of different histology. Both H2-M isoforms promote equally processing and presentation of native protein antigens to H2-A[SUPd]- and H2-E[SUPd]-restricted CD4+ T cells. Murine tumour cell lines could be divided into three groups: constitutive MHC class II and CIITA expression; inducible MHC class II and CIITA expression upon IFN-γ-treatment; and lack of constitutive and IFN-γ-inducible MHC class II and CIITA expression. These differences may impact on CD4+ T cell recognition of cancer cells in murine tumour models. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MAJOR histocompatibility complex
*TUMOR antigens
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 83
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 8876588
- Full Text :
- https://doi.org/10.1054/bjoc.2000.1415