Another genotoxic agent released by mitochondrial meltdown.

Editorial. Looks at the probable role of endonuclease G, a protein of the pro-apoptotic family, in causing cell death. Effect of mitochondrial damage in the dysregulation of its ancestral toxin/antitoxin component with consequent cell death; Involvement of endonuclease G in nuclear DNA disagregation; Need to know whether endonuclease G can cause death by itself.