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Cuprate Addition to a 6-Substituted Pentafulvene - Preparation of sec-Alkyl-Substituted Titanocene Dichlorides and Their Biological Activity.
- Source :
-
European Journal of Organic Chemistry . Sep2013, Vol. 2013 Issue 19, p3997-4007. 11p. - Publication Year :
- 2013
-
Abstract
- The copper-catalysed (10 mol-% CuBr ·SMe2, CuCN ·LiCl or CuI/PPh3) addition of RMgBr to the pentafulvene 1-(cyclopenta-2,4-dien-1-ylidenemethyl)-2-methoxybenzene allows the formation of cyclopentadienyl derivatives with α-CHR(2-MeOPh) sidechains (R = Me, Et, nBu, iBu, allyl, Ph) without H- transfer. The deprotonation of these sec-alkyl-substituted cyclopentadienyls followed by the addition of TiCl4 allows the isolation of TiCl2{η5-C5H4CHR(2-OMePh)} as rac/ meso mixtures that show activity against human colon, breast and pancreatic cell lines (GI50 2.3-42.4 μ M). [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANISOLE
*CYCLOPENTADIENE
*CELL lines
*COLON (Anatomy)
*CUPRATES
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2013
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 88263308
- Full Text :
- https://doi.org/10.1002/ejoc.201300474