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Targeting tumours with genetically enhanced T lymphocytes.
- Source :
-
Nature Reviews Cancer . Jan2003, Vol. 3 Issue 1, p35-45. 11p. - Publication Year :
- 2003
-
Abstract
- The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*GENETIC transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1474175X
- Volume :
- 3
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 8818859
- Full Text :
- https://doi.org/10.1038/nrc971