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Production of atypical measles in rhesus macaques: Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody.
- Source :
-
Nature Medicine . Jun1999, Vol. 5 Issue 6, p629. 6p. - Publication Year :
- 1999
-
Abstract
- The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and fusion-inhibiting antibodies, but no cytotoxic Tcell response. Subsequent infection with measles virus caused an atypical rash and pneumonitis, accompanied by immune complex deposition and an increase in eosinophils. Fusion-inhibiting antibody appeared earlier in these monkeys than in non-immunized monkeys. These data indicate that atypical measles results from previous priming for a nonprotective type 2 CD4 T-cell response rather than from lack of functional antibody against the fusion protein. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MEASLES
*MEASLES vaccines
*IMMUNE complexes
*EOSINOPHILS
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 5
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8818036
- Full Text :
- https://doi.org/10.1038/9473