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Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress.
- Source :
-
Nature Medicine . Dec2000, Vol. 6 Issue 12, p1355. 7p. - Publication Year :
- 2000
-
Abstract
- Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to trigger expression of pivotal regulators of inflammation, coagulation and vascular hyperpermeability. Chemokine, adhesion receptor, procoagulant and permeability-related genes are coordinately upregulated by rapid ischemia-mediated activation of Egr-1. Deletion of the gene encoding Egr-1 strikingly diminished expression of these mediators of vascular injury in a murine model of lung ischemia/reperfusion, and enhanced animal survival and organ function. Rapid activation of Egr-1 in response to oxygen deprivation primes the vasculature for dysfunction manifest during reperfusion. These studies define a central and unifying role for Egr-1 activation in the pathogenesis of ischemic tissue damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ISCHEMIA
*TRANSCRIPTION factors
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 6
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8817543
- Full Text :
- https://doi.org/10.1038/82168