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Solution structure of the PX domain, a target of the SH3 domain.
- Source :
-
Nature Structural Biology . Jun2001, Vol. 8 Issue 6, p526. 5p. - Publication Year :
- 2001
-
Abstract
- The phox homology (PX) domain is a novel protein module containing a conserved proline-rich motif. We have shown that the PX domain isolated from the human p47phox protein, a soluble subunit of phagocyte NADPH oxidase, binds specifically to the C-terminal SH3 domain derived from the same protein. The solution structure of p47 PX has an α + β structure with a novel folding motif topology and reveals that the proline-rich motif is presented on the molecular surface for easy recognition by the SH3 domain. The proline-rich motif of p47 PX in the free state adopts a distorted left-handed polyproline type II helix conformation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HOMOLOGY (Biology)
*PROTEINS
*PROLINE
Subjects
Details
- Language :
- English
- ISSN :
- 10728368
- Volume :
- 8
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Structural Biology
- Publication Type :
- Academic Journal
- Accession number :
- 8816984
- Full Text :
- https://doi.org/10.1038/88591