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Childhood passive smoke exposure is associated with adult head and neck cancer.
- Source :
-
Cancer Epidemiology . 2013, Vol. 37 Issue 4, p417-423. 7p. - Publication Year :
- 2013
-
Abstract
- Introduction: Passive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain. Methods: We conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression. Results: CPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01-1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80-1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with human papillomavirus (HPV) infection) than with HNSCC at nonoropharyngeal sites (OR, 2.02; 95% CI, 1.01-4.06, N = 52 cases vs. OR, 1.04; 95% CI, 0.68-1.60, N = 132 cases; P-for-heterogeneity = 0.08). Conclusions: Data from this large US-based case control study suggest a role for CPSE in HNSCC etiology. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18777821
- Volume :
- 37
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Cancer Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 88157984
- Full Text :
- https://doi.org/10.1016/j.canep.2013.03.011