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Differences in morphine-induced antinociception in male and female offspring born of morphine exposed mothers.
- Source :
-
Indian Journal of Pharmacology . May/Jun2013, Vol. 45 Issue 3, p227-231. 5p. 3 Graphs. - Publication Year :
- 2013
-
Abstract
- Objective: Antinociceptive effect of morphine in offspring born of mothers that received saline or morphine during the gestation period was investigated. Materials and Methods: Wistar rats (200-250 g) received saline, morphine 0.5 mg/kg or 5 mg/kg during gestation days 14-16. All pups after weaning were isolated treatment/sex dependently and were allowed to fully mature. The antinociceptive effect of morphine was assessed in formalin test. Morphine (0.5-7.5 mg/kg) or saline (1 ml/kg) was injected intraperitoneally 10 min before formalin (50 μl of 2.5% solution in right hind-paw). Results: Male offspring born of saline-treated mothers were less morphine-sensitive than females. On the contrary, male offspring exposed prenatally to morphine (5 mg/kg) were more sensitive to morphine-induced antinociceptive response in formalin test. However, no difference in antinociceptive effect was observed amongst offspring of either sex born of mothers treated with morphine 0.5 mg/kg, identifying a lower dose effect of the opioid. Conclusion: The exposure to morphine during the developmental period may result in altered development of tolerance to morphine and thus involved in drug abuse. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02537613
- Volume :
- 45
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 87956926
- Full Text :
- https://doi.org/10.4103/0253-7613.111904