Peculiarities of Amnesia Development during Memory Reconsolidation Impairment Induced by Isolated or Combined Treatment with Neurotransmitter Receptor Antagonists.

The effects of serotonin and glutamate receptor antagonists on conditioned food aversion memory reconsolidation were studied in experiments on edible snails. Injections of NMDA and AMPA glutamate receptor antagonists to trained snails before the reminder were found to induce the development of 'irreversible' amnesia: repeated training of these animals was not followed by memory formation. Administration of serotonin receptor antagonist before the reminder led to the development of 'reversible' amnesia, repeated training was followed by memory formation. The combined administration of serotonin receptor antagonist with NMDA and AMPA receptor antagonists partially or completely abolished amnesia development. We hypothesized that that both memory reconsolidation and amnesia induction require integration of specific patterns converging to neurons and involving certain types of neurotransmitter receptors. [ABSTRACT FROM AUTHOR]