Possíveis interações medicamentosas entre os anti-hipertensivos e antidiabéticos em participantes do Grupo HIPERDIA de Parobé, RS (Uma análise teórica).

Owing to the high incidence of concurrent hypertension and diabetes mellitus, it is common to find patients using antihypertensive and anti-diabetic drugs simultaneously. Thus, it is important to identify drug interactions in the treatment of hypertension and diabetes and to carry out pharmacotherapy monitoring to avoid serious adverse effects or even death. The aim in this was to identify potential interactions between antihypertensive and hypoglycemic agents in elderly participants of the group Hiperdia in the town of Parobé (RS). This is a cross-sectional, quantitative and observational study and was conducted by means of a structured questionnaire applied to 45 (39 elderly, 37 with drug interactions) members of the group. We identified 144 potential drug interactions, 30% of which were desirable and 70% undesirable. Among the latter, 85% were classified as moderate, the most frequent association being that of captopril and acetylsalicylic acid, 5% as severe (interaction of loop diuretics with digitalis) and 10% as light. Among the desirable interactions, the combination of captopril and hydrochlorothiazide occurred most frequently. This study revealed a high rate of potential drug interactions in elderly members of Hiperdia. Most interactions can jeopardize patient safety, highlighting the importance of this matter and the need to assess and monitor drug therapy in the elderly, in order to prevent and mitigate the consequences of potential drug interactions. [ABSTRACT FROM AUTHOR]