Synthesis of Unsymmetrical 2-Pyridyl Ureas via Selenium-Catalyzed Oxidative Carbonylation of 2-Aminopyridine with Aromatic Amines.

A simple, one-pot, phosgene-free approach to a series of unsymmetrical 2-pyridyl ureas starting from 2-aminopyridine and various aromatic amines is reported for the first time. The procedure employs inexpensive selenium as the catalyst, and carbon monoxide (instead of phosgene) as the carbonyl reagent. The products are ob-tained in moderate to good yields via selenium-catalyzed oxidative cross-carbonylation of the substrate amines in the presence of oxy-gen. The selenium functions as a phase-transfer catalyst and can be recovered easily and reused without any significant degradation of its catalytic activity. [ABSTRACT FROM AUTHOR]