TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors

Abstract: Polymorphic, deoxythymidine-tract in intron 6 of the TOMM40 gene has been associated with Alzheimer''s disease. We have investigated the impact of this polymorphism on Parkinson''s disease risk and age of onset, independently and in combination with apolipoprotein E alleles, in a group of 407 PD patients and 305 control subjects. No significant association was observed at the single allele, genotype, or haplotype levels. Our data suggest that the polymorphism is not a risk factor for Parkinson''s disease in the Polish population. [Copyright &y& Elsevier]