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Tolerance-induction protocol in HIV-infected patients with drug hypersensitivity
- Source :
-
Revue Francaise d'Allergologie & d'Immunologie Clinique . Dec2002, Vol. 42 Issue 8, p757. 6p. - Publication Year :
- 2002
-
Abstract
- HIV-infected patients are at greater risk for drug hypersensitivity than non-HIV-infected patients. Sulfonamides and anti-retroviral drugs are most often the responsible agents. We detail in this paper our 5-year experience with this problem. Ninety-three HIV-positive patients with a clear history of hypersensitivity to cotrimoxazole, nevirapine, nelfinavir or efavirenz were included in a tolerance-induction protocol. The clinical manifestations were as follows: 68 patients had had pruriginous maculo-papular eruptions including 17 with fever and 12 with other symptoms (conjunctivitis, asthenia, digestive symptoms, etc). Fourteen patients presented with urticaria, with fever in 4 of them. Twelve doses of the responsible drug, prepared the day of the challenge, were given orally at 30-minute intervals. We were successful in 90% of the cases. Therefore, tolerance induction may be an alternative for such patients. [Copyright &y& Elsevier]
- Subjects :
- *BIOCOMPATIBILITY
*ALLERGIES
*HIV infections
Subjects
Details
- Language :
- French
- ISSN :
- 03357457
- Volume :
- 42
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Revue Francaise d'Allergologie & d'Immunologie Clinique
- Publication Type :
- Academic Journal
- Accession number :
- 8722033
- Full Text :
- https://doi.org/10.1016/S0335-7457(02)00224-1