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Prenatal and Postnatal Bisphenol A Exposure and Body Mass Index in Childhood in the CHAMACOS Cohort.
- Source :
-
Environmental Health Perspectives . Apr2013, Vol. 121 Issue 4, p514-520. 7p. 3 Charts, 1 Graph. - Publication Year :
- 2013
-
Abstract
- Background: Bisphenol A (BPA), a widely used endocrine-disrupting chemical, has been associated with increased body weight and fat deposition in rodents. Objectives: We examined whether prenatal and postnatal urinary BPA concentrations were associated with body mass index (BMI), waist circumference, percent body fat, and obesity in 9-year-old children (n = 311) in the CHAMACOS longitudinal cohort study. Methods: BPA was measured in spot urine samples collected from mothers twice during pregnancy and from children at 5 and 9 years of age. Results: Prenatal urinary BPA concentrations were associated with decreased BMI at 9 years of age in girls but not boys. Among girls, being in the highest tertile of prenatal BPA concentrations was associated with decreased BMI z-score (β = -0.47, 95% CI: -0.87, -0.07) and percent body fat (β = -4.36, 95% CI: -8.37, -0.34) and decreased odds of overweight/obesity [odds ratio (OR) = 0.37, 95% CI: 0.16, 0.91] compared with girls in the lowest tertile. These findings were strongest in prepubertal girls. Urinary BPA concentrations at 5 years of age were not associated with any anthropometric parameters at 5 or 9 years, but BPA concentrations at 9 years were positively associated with BMI, waist circumference, fat mass, and overweight/obesity at 9 years in boys and girls. Conclusions: Consistent with other cross-sectional studies, higher urinary BPA concentrations at 9 years of age were associated with increased adiposity at 9 years. However, increasing BPA concentrations in mothers during pregnancy were associated with decreased BMI, body fat, and overweight/obesity among their daughters at 9 years of age. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANALYSIS of variance
*CONFIDENCE intervals
*EPIDEMIOLOGY
*INTERVIEWING
*LONGITUDINAL method
*RESEARCH methodology
*CHILDHOOD obesity
*PROBABILITY theory
*RESEARCH funding
*STATISTICS
*DATA analysis
*MULTIPLE regression analysis
*BODY mass index
*CROSS-sectional method
*DATA analysis software
*DESCRIPTIVE statistics
*PRENATAL exposure delayed effects
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 121
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 87071686
- Full Text :
- https://doi.org/10.1289/ehp.1205548