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Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2.
- Source :
-
Science . 11/1/2002, Vol. 298 Issue 5595, p1025-1029. 5p. 1 Chart, 3 Graphs. - Publication Year :
- 2002
-
Abstract
- β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDE antibiotics
*IMMUNE system
*MICROBIAL inoculants
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 298
- Issue :
- 5595
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 8678896
- Full Text :
- https://doi.org/10.1126/science.1075565