Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.

Presents a study that examined the role of the mammalian proto-oncogene Cbl in the regulation of the Src-family kinase hematopoietic cell kinase (Hck) by targeting its degradation. Background on the regulators of growth factor signaling pathways; Impact of pharmacological inhibition of the proteasome on Hck; Analysis of physiological responses caused by the transduction of extracellular signals.