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Long-term clinical outcome of patients with soft tissue sarcomas treated with limb-sparing surgery and postoperative radiotherapy.
- Source :
-
Acta Oncologica . May2013, Vol. 52 Issue 4, p745-752. 8p. 4 Charts, 2 Graphs. - Publication Year :
- 2013
-
Abstract
- Background. To evaluate long-term local control, survival, radiation side effects and functional outcome after limb-sparing surgery followed by postoperative radiotherapy (RT) for soft tissue sarcoma (STS). Material and methods. Between 1995 and 2010, 118 patients with STS of an extremity were treated with limb-sparing surgery and postoperative RT. Follow-up was complete for all patients. Acute and late radiation related toxicities were scored using CTCAE v4.0. Results. Median follow-up was 93 months. RT dose was 60 Gy in 92.4% of the patients; 5.1% received 66 Gy; 2.5% 50-56 Gy. Actuarial local recurrence rates at five and 10 years were 9% and 12%. Five- and 10-year overall survival rates were 69% and 51%. Acute radiation toxicities occurred in 91% of the patients; 19% were grade 3, 2% grade 4. Late radiation toxicities were reported in 71% of the patients: 50% grade 1, 18% grade 2, and 3% grade 3. Limb and joint function after treatment were good, 19% having mild limitation of motion, 1.5% moderate, and 2.5% severe limitations. Conclusion. Limb-sparing surgery with 60 Gy postoperative radiotherapy for patients with STS provides excellent local control and high survival rates with acceptable toxicity and functional outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CONFIDENCE intervals
*LEG
*HEALTH outcome assessment
*RADIOTHERAPY
*SARCOMA
*SCALES (Weighing instruments)
*SOFT tissue tumors
*SURVIVAL analysis (Biometry)
*DISEASE relapse
*TREATMENT effectiveness
*PROPORTIONAL hazards models
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 0284186X
- Volume :
- 52
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Acta Oncologica
- Publication Type :
- Academic Journal
- Accession number :
- 86727037
- Full Text :
- https://doi.org/10.3109/0284186X.2012.709947