Vesicular particles directly assembled from the cyclodextrin/UR-144 supramolecular amphiphiles

Abstract: Vesicles constructed by supramolecular amphiphiles are considered as more promising stimuli-responsive vehicles for carrying and delivering targeted molecules. In this research, novel supramolecular amphiphiles are directly assembled from UR-144, a general neuropathic drug, and a class of mono-diaminoalkane substituted β-cyclodextrins. In the aqueous solution, the supramolecular amphiphiles can assemble into vesicular particles, which were characterized in detail by transmission electron microscopy (TEM), atomic force microscopy (AFM), scanning electron microscopy (SEM) and dynamic light scattering (DLS). The mechanism was also suggested based on the NMR, Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) experimental results. The vesicular particles tend to be damaged upon the addition of Cu2+ and meanwhile release UR-144. [Copyright &y& Elsevier]