Transmission of p-anisic acid through nanofiltration and goat membranes

Abstract: The aim of this work was to study the transmission of p-anisic acid through two different membranes, viz., commercially available nanofiltration membrane (NF-300) and a goat membrane. The p-anisic acid is a crystalline organic compound having vital applications in medical science for the treatment of Parkinson''s disease, hepatitis B and C viruses, liver diseases, post radiation treatment of breast cancer, and skin desquamation. The study of transmission (or rejection) of material and change in the permeate flux have been made with respect to changes in feed concentration, pH, cross flow velocity, time and temperature and found that the transmission of p-anisic acid is affected by the type of membrane, its pore size and structure of pores. Also a study pertaining to the mass transfer coefficient has been made and evaluated the same with different theories. Mass transfer of p-anisic acid is explained in a better way by the simple graphical theory. The transmission of p-anisic acid is affected by the membrane structure and its type. A higher transmission was observed through the goat membrane. Using nanosize particles the drug dosage can be reduced with better diffusion, further, toxicological aspects can also be reduced. [Copyright &y& Elsevier]