Enantioselective Total Syntheses of (+)-Gallocatechin, (−)-Epigallocatechin, and 8-C-Ascorbyl-(−)-epigallocatechin.

Reading the tea leaves: The enatioselective total syntheses of 8 ‐ C ‐ ascorbyl ‐ (−) ‐ epigallocatechin was accomplished by CuII ‐ mediated oxidative coupling of ascorbic acid and (−) ‐ epigallocatechin as a key step. Also, the asymmetric total syntheses of tea ‐ leaf extracts (+) ‐ gallocatechin and (−) ‐ epigallocatechin were achieved by Au ‐ catalyzed intramolecular cycliarylation of the precursor epoxide and Sharpless dihydroxylation. [ABSTRACT FROM AUTHOR]