Back to Search
Start Over
Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium
- Source :
-
Materials Science & Engineering: C . May2013, Vol. 33 Issue 4, p2392-2398. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: The present study investigates the potential use of non-catalyzed water-soluble blocked polyurethane prepolymer (PUP) as a bifunctional cross-linker for collagenous scaffolds. The effect of concentration (5, 10, 15 and 20%), time (4, 6, 12 and 24h), medium volume (50, 100, 200 and 300%) and pH (7.4, 8.2, 9 and 10) over stability, microstructure and tensile mechanical behavior of acellular pericardial matrix was studied. The cross-linking index increased up to 81% while the denaturation temperature increased up to 12°C after PUP crosslinking. PUP-treated scaffold resisted the collagenase degradation (0.167±0.14mmol/g of liberated amine groups vs. 598±60mmol/g for non-cross-linked matrix). The collagen fiber network was coated with PUP while viscoelastic properties were altered after cross-linking. The treatment of the pericardial scaffold with PUP allows (i) different densities of cross-linking depending of the process parameters and (ii) tensile properties similar to glutaraldehyde method. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 33
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 86155222
- Full Text :
- https://doi.org/10.1016/j.msec.2013.02.001