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Effect of tibolone and raloxifene on serum markers of apoptosis in postmenopausal women.
- Source :
-
Climacteric . Apr2013, Vol. 16 Issue 2, p258-264. 7p. - Publication Year :
- 2013
-
Abstract
- Objectives To investigate the effect of tibolone and raloxifene on the serum apoptotic markers soluble Fas (sFas), soluble Fas ligand (sFasL) and cytochrome-c (cyt-c) in postmenopausal women. Methods A total of 89 healthy postmenopausal women, attending the University Menopause Clinic, were randomly allocated to tibolone ( n =30), raloxifene ( n =29) or no treatment ( n =30). Serum apoptotic markers sFas, sFasL and cyt-c were measured at baseline and at 6 months. Results Serum sFasL decreased significantly in women receiving tibolone (baseline: 53.8±28.3 pg/ml, 6 months: 40.45±19.2 pg/ml, p =0.001), whilst sFas levels did not significantly change in this group. Serum sFas or sFasL did not change either in the raloxifene group or in the control group. Serum cyt-c concentrations were under the detection limit of the assay in all women assessed. Conclusions Tibolone use resulted in a significant decrease in serum sFasL, but not in serum sFas. Raloxifene had no effect on either sFas or sFasL. These results may indicate that tibolone use is associated with a decrease in receptor-mediated apoptosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RALOXIFENE
*APOPTOSIS
*POSTMENOPAUSE
*SERUM
*WOMEN'S health
Subjects
Details
- Language :
- English
- ISSN :
- 13697137
- Volume :
- 16
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Climacteric
- Publication Type :
- Academic Journal
- Accession number :
- 86059791
- Full Text :
- https://doi.org/10.3109/13697137.2012.668251