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Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells
- Source :
-
Biochemical & Biophysical Research Communications . Dec2002, Vol. 299 Issue 5, p886. 5p. - Publication Year :
- 2002
-
Abstract
- It seems certain that COX-2 is related to tumor and some data suggested that COX-2 might have relation to tumor malignance and angiogenesis. In order to elucidate the relationship between COX-2 and tumor invasive and angiogenic ability, we transfected human transitional cell carcinoma (TCC) cell line, EJ, permanently with a COX-2 expression vector or the mock vector. The EJ-<f>COX2</f> cells, which overexpressed COX-2, acquired increased invasiveness and angiogenic ability by activation of VEGF, uPA, and MMP-2. Increased invasiveness and angiogenic ability were reversed by treatment with either selective COX-2 inhibitor, NS-398, or dual COX inhibitor, indomethacin. These results demonstrate that overexpression of COX-2 can lead to phenotypic changes that alter the metastatic and angiogenic potential of TCC cancer cells. [Copyright &y& Elsevier]
- Subjects :
- *CYCLOOXYGENASE 2
*NEOVASCULARIZATION
*CANCER invasiveness
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 299
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 8578970
- Full Text :
- https://doi.org/10.1016/S0006-291X(02)02707-9