A Theory of Hemispheric Specialization Based on Cortical Columns.

Hemispheric function specialization and associated neuroanatomical characteristics have been a topic of interest for many years. In this regard, mechanisms of cortical processing and memory storage have proven elusive. The current paper proposes that a model of cortical processing based on the column has the potential for explaining laterality of function and memory. Memory formation is defined as the strengthening of synaptic connections in any given circuit of cortical columns, while forgetting is defined as weakened synaptic connections with failure to activate downstream columns in any given circuit. Following a discussion of the cortical column, it is suggested that speed and quantity of columnar activation can explain laterality findings. However, several additional aspects of columnar interaction patterns must be considered to explain the regional differences within each of the hemispheres. The paper concludes with a discussion of current approaches that offer a means to test the model's validity. [ABSTRACT FROM AUTHOR]