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Comparison of Tamoxifen with Edible Seaweed ( Eucheuma cottonii L.) Extract in Suppressing Breast Tumor.
- Source :
-
Nutrition & Cancer . Feb2013, Vol. 65 Issue 2, p255-262. 8p. 2 Color Photographs, 1 Chart. - Publication Year :
- 2013
-
Abstract
- The tropical edible red seaweed (Eucheuma cottoniiL.) is rich in nutrients and polyphenolic compounds that may suppress cancer through its antioxidant and antiproliferative properties. The study reports on rat mammary tumor suppression and tissue antioxidant status modulation byE. cottoniiethanol extract (ECE). The effect of orally administered ECE (100 mg/kg body-weight) was compared with that of tamoxifen (10 mg/kg body-weight). Rat was induced to develop mammary tumor with subcutaneous injection of LA-7 cells (6 × 106cells/rat). The ECE was more effective than tamoxifen in suppressing tumor growth (27%), improving tissues (plasma, liver, and kidney) malondialdehyde concentrations, superoxide dismutase activity and erythrocyte glutathione concentrations (P< 0.05). Unlike tamoxifen, the ECE displayed little toxicity to the liver and kidneys. The ECE exhibited strong anticancer effect with enzyme modulating properties, suggesting its potential as a suppressing agent for mammary gland tumor. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST tumor treatment
*TAMOXIFEN
*DNA
*PHENOLS
*ERYTHROCYTES
*ANIMAL experimentation
*BODY weight
*BREAST tumors
*CANCER chemotherapy
*CELL physiology
*DOXORUBICIN
*KIDNEYS
*LIVER
*EVALUATION of medical care
*MEDICINAL plants
*LIPID peroxidation (Biology)
*NUTRITION
*OXIDATION-reduction reaction
*OXYGEN
*RADIOTHERAPY
*RATS
*T-test (Statistics)
*DATA analysis
*DATA analysis software
*DESCRIPTIVE statistics
*THERAPEUTICS
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 65
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 85759988
- Full Text :
- https://doi.org/10.1080/01635581.2013.756528