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Synthesis, characterization, and NF-κB pathway inhibition of 1-halogenated sinomenine derivatives.
- Source :
-
Chemistry of Natural Compounds . Jan2013, Vol. 48 Issue 6, p1031-1034. 4p. 1 Diagram, 1 Chart. - Publication Year :
- 2013
-
Abstract
- A series of 1-halogenated sinomenine derivatives was designed and prepared. All synthesized derivatives were structurally confirmed by ESI-MS, PMR. The inhibition of the NF-κB pathway in vitro was evaluated with pNF-κB-luc cell lines. The derivatives 5b, 6a, 6c, and 7a inhibited NF-κB action with IC values lower than that of sinomenine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMICAL derivatives
*CELL lines
*HALOGENATION
*HALOGEN compounds
*DERIVATIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 48
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 85715644
- Full Text :
- https://doi.org/10.1007/s10600-013-0457-8