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Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists
- Source :
-
Bioorganic & Medicinal Chemistry . Mar2013, Vol. 21 Issue 5, p1349-1356. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: GPR119 agonist has emerged as a promising target for the treatment of type 2 diabetes. A series of novel 2,4-disubstituted quinazoline analogues was prepared and evaluated their agonistic activity against human GPR119. The analogues bearing azabicyclic amine substituents (12a, 12c and 12g) exhibited better EC50 values than that of OEA though they appeared to be partial agonists. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 21
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 85619159
- Full Text :
- https://doi.org/10.1016/j.bmc.2012.12.013