Does sucralfate reduce early side effects of pelvic radiation? A double-blind randomized trial

Study and methods: A double-blind placebo-controlled study randomized 108 patients to investigate the effect of sucralfate on gastrointestinal side effects of pelvic radiation.Results: Overall, pelvic radiation with the administered doses and fields and performed according to nowadays technical standards, was well tolerated. Comparison of the mean scores and the peak reactions for radiotherapy discomfort, diarrhoea and number of stools per day in the 80 evaluable patients showed no statistically significant difference between sucralfate and placebo.Conclusion: Based on these results, the use of sucralfate can not be recommended as standard practice. [Copyright &y& Elsevier]