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Role of NKp46 Expression in Cytokine Production by CD56-Positive NK Cells in the Peripheral Blood and the Uterine Endometrium.
- Source :
-
American Journal of Reproductive Immunology . Mar2013, Vol. 69 Issue 3, p202-211. 10p. 2 Charts, 4 Graphs. - Publication Year :
- 2013
-
Abstract
- Problem To investigate the role of natural cytotoxicity receptor, NKp46 expression in cytokine-producing NK cells. Method of Study CD56+/ NKp46+ NK cells from the peripheral blood and the uterine endometrium were magnetically separated. IFN-γ, TNF-α, IL-4, IL-10, and TGF-β1 expressions on NK cells were investigated using multicolor flow cytometry. Results Peripheral blood and uterine endometrial NK cells were grouped into 4 subpopulations based upon the degree of CD56 and NKp46 expressions. NKp46 expression was associated with higher frequency of cytokine-producing NK cells, including CD56dim NK cells. The percentage of TNF-α+ and IL-10+ NK cells per total CD56+/ NKp46+ NK cells in the uterine endometrium showed a significant correlation with those of the peripheral blood in all subpopulations, but that of IFN-γ+, IL-4+, and TGF-β1+ NK cells showed partial correlation. Conclusion Expression of NKp46 is involved in cytokine production of CD56+ NK cells in the peripheral blood and the uterine endometrium. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10467408
- Volume :
- 69
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- American Journal of Reproductive Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 85317492
- Full Text :
- https://doi.org/10.1111/aji.12062