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Immediate post-resection diabetes mellitus after pancreaticoduodenectomy: incidence and risk factors.
- Source :
-
HPB . Mar2013, Vol. 15 Issue 3, p170-174. 5p. - Publication Year :
- 2013
-
Abstract
- Background: New-onset diabetes mellitus after a pancreaticoduodenectomy (PD) remains poorly defined. The aim of this study was to define the incidence and predictive factors of immediate post-resection diabetes mellitus (iPRDM). Methods: Retrospective review of patients undergoing PD from January 2004 through to July 2010. Immediate post-resection diabetes mellitus was defined as diabetes requiring pharmacological treatment within 30 days post-operatively. Logistic regression was conducted to identify factors predictive of iPRDM. Results: Of 778 patients undergoing PD, 214 were excluded owing to pre-operative diabetes ( n= 192), declined research authorization ( n= 14) or death prior to hospital discharge ( n= 8); the remaining 564 patients comprised the study population. iPRDM occurred in 22 patients (4%) who were more likely to be male, have pre-operative glucose intolerance, or an increased creatinine, body mass index (BMI), pre-operative glucose, operative time, tumour size or specimen length compared with patients without iPRDM ( P < 0.05). On multivariate analysis, pre-operative impaired glucose intolerance ( P < 0.001), pre-operative glucose ≥ 126 ( P < 0.001) and specimen length ( P= 0.002) were independent predictors of iPRDM. A predictive model using these three factors demonstrated a c-index of 0.842. Discussion: New-onset, post-resection diabetes occurs in 4% of patients undergoing PD. Factors predictive of iPRDM include pre-operative glucose intolerance, elevated pre-operative glucose and increased specimen length. These data are important for patient education and predicting outcomes after PD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIABETES
*PANCREATICODUODENECTOMY
*DUODENECTOMY
*PANCREATECTOMY
*ENDOCRINE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 1365182X
- Volume :
- 15
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- HPB
- Publication Type :
- Academic Journal
- Accession number :
- 85281459
- Full Text :
- https://doi.org/10.1111/j.1477-2574.2012.00520.x