Back to Search
Start Over
A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats
- Source :
-
Epilepsy & Behavior . Feb2013, Vol. 26 Issue 2, p196-202. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: According to different studies, between 5% and 10% of people suffer a single isolated seizure episode at some time in their life. However, little is known about the effects of a single seizure episode on cognitive function, and clinical investigations of this issue are not easy to perform. In this situation, animal models may be a reasonable choice. The aim of our study was to follow the time course of delayed effects of generalized clonic-tonic convulsions on learning and memory functions in rats. A clonic-tonic seizure episode was induced by a single i.p. injection of pentylenetetrazole (70mg/kg). Different behavioral tests were performed between days 10 and 100 after the convulsant administration. A single seizure episode resulted in a gradual decline in short-term memory function as assessed by novel object recognition and social recognition tests. The seizure episode induced a quick increase in hippocampal cell proliferation; however, the excessive newly generated cells seemed to be eliminated by the time of obvious cognitive impairment. These observations are indicative of a slowly developing and long-lasting influence of a single seizure episode on cognitive function. A rather long time period between the seizure episode and the manifestations of cognitive decline provides a window for a possible therapeutic intervention, and an elaboration of such “post-conditioning” treatments may be a promising opportunity to prevent subsequent mental impairments in patients. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15255050
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Epilepsy & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 85017819
- Full Text :
- https://doi.org/10.1016/j.yebeh.2012.12.006