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A case of opportunistic skin infection with Mycobacterium marinum during adalimumab treatment in a patient with Crohn's disease
- Source :
-
Journal of Crohn's & Colitis . Feb2013, Vol. 7 Issue 1, pe15-e18. 0p. - Publication Year :
- 2013
-
Abstract
- Abstract: Opportunistic infections, especially reactivation with M. tuberculosis, are major complications during treatment with anti-TNF agents. Infections with atypical mycobacteria like Mycobacterium marinum are rare and tend to turn into a difficult and prolonged course due to delayed diagnosis. This is the first case of M. marinum infection during adalimumab therapy in a patient with Crohn''s disease. The most important diagnostic step was a detailed medical history as PCR tested for M. tuberculosis and for atypical subspecies was false negative. Up to now a discontinuation of anti-TNF therapy has been recommended, however, there is no consensus about the reintroduction of biologicals after sufficient anti-infective therapy. In this patient anti-TNF therapy had to be reintroduced because of increasing activity with no relapse of M. marinum after a follow-up of 12months. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 18739946
- Volume :
- 7
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Crohn's & Colitis
- Publication Type :
- Academic Journal
- Accession number :
- 84772778
- Full Text :
- https://doi.org/10.1016/j.crohns.2012.04.015