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Cadmium Exposure and Pancreatic Cancer in South Louisiana.
- Source :
-
Journal of Environmental & Public Health . 2012, p1-11. 11p. 3 Charts. - Publication Year :
- 2012
-
Abstract
- Cadmium has been hypothesized to be a pancreatic carcinogen. We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana). We tested potential dietary and nondietary sources of cadmium for their association with urinary cadmium concentrations which reflect long-termexposure to cadmium due to the accumulation of cadmium in the kidney cortex. Increasing urinary cadmium concentrations were significantly associated with an increasing risk of pancreatic cancer (2nd quartile OR = 3.34, 3rd = 5.58, 4th = 7.70; test for trend P ⩽ 0.0001). Potential sources of cadmium exposure, as documented in the scientific literature, found to be statistically significantly associated with increased risk of pancreatic cancer included working as a plumber, pipefitter or welder (OR = 5.88) and high consumption levels of red meat (4th quartile OR = 6.18) and grains (4th quartile OR = 3.38). Current cigarette smoking, at least 80 pack years of smoking, occupational exposure to cadmium and paints, working in a shipyard, and high consumption of grains were found to be statistically significantly associated with increased concentrations of urinary cadmium. This study provides epidemiologic evidence that cadmium is a potential human pancreatic carcinogen. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16879805
- Database :
- Academic Search Index
- Journal :
- Journal of Environmental & Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 84667748
- Full Text :
- https://doi.org/10.1155/2012/180186