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The Association of Antioxidants and Cognition in the Nurses’ Health Study.
- Source :
-
American Journal of Epidemiology . Jan2013, Vol. 177 Issue 1, p33-41. 9p. - Publication Year :
- 2013
-
Abstract
- The authors examined long-term antioxidant intake in relation to cognitive decline among older women. Beginning in 1980, Nurses’ Health Study (NHS) participants completed dietary assessments every 4 years; in 1995–2001, 16,010 participants aged ≥70 years completed initial cognitive assessments, which were repeated 3 times at 2-year intervals. Long-term antioxidant intake was averaged from 1980 through the time of initial cognitive interviews. Multivariable-adjusted linear regression was used to estimate mean differences in rates of cognitive decline across categories of vitamin E, vitamin C, and carotenoid intake; statistical tests were 2-sided. No associations were evident for vitamin E or total carotenoid intake and cognitive decline (e.g., after multivariable adjustment, P-trend = 0.44 and P-trend = 0.51, respectively, for a global composite score averaging all 6 cognitive tests), although higher lycopene intake and lower vitamin C intake were related to slower cognitive decline. In alternative analyses of overall cognitive status at older ages (averaging all 4 cognitive assessments), results for vitamins E and C were generally null, but higher carotenoid intake was related to better cognition. Overall, long-term vitamin E and C intakes were not consistently related to cognition, although greater consumption of carotenoids may have cognitive benefits in older adults. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *THERAPEUTIC use of antioxidants
*NURSES
*AGING
*CAROTENOIDS
*COGNITION
*CONFIDENCE intervals
*STATISTICAL correlation
*EPIDEMIOLOGY
*INGESTION
*LONGITUDINAL method
*NEUROPSYCHOLOGICAL tests
*QUESTIONNAIRES
*RESEARCH funding
*VITAMIN C
*VITAMIN E
*DATA analysis
*MULTIPLE regression analysis
*REPEATED measures design
*DESCRIPTIVE statistics
*NULL hypothesis
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 177
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 84596148
- Full Text :
- https://doi.org/10.1093/aje/kws202