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Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study.
- Source :
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BMC Public Health . 2012, Vol. 12 Issue 1, p634-642. 9p. 3 Charts, 2 Graphs. - Publication Year :
- 2012
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Abstract
- Background: Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). The purpose of this study was to investigate the relationship between lipid profiles and β cell function in Chinese individuals with NGT but without history of diabetes or prediabetes. Methods: A total of 893 men and 1454 women aged 18-76 years living in Sichuan, China, who were not being treated with lipid-lowering drugs were enrolled in this study. Insulin sensitivity (IR) was evaluated using the homeostasis model assessment -IR (HOMA-IR), β-cell function was calculated by the following equation: ΔI30/ ΔG30/ HOMA-IR (Δ;I30/ΔG30: the ratio of incremental glucose and insulin 30 min after glucose intake). Multivariate linear regression analyses were performed to estimate the relationship between blood lipid and β cell function as standardized coefficients (β). Results: β cell function decreased in men and women with increasing age. We found inverse relationships between β cell function and total cholesterol (TC) in men and women (β = -0.157 and -0.113, respectively, both p < 0.001), low-density lipoprotein-cholesterol (LDL-C; β = -0.130 and -0.068, respectively, both p < 0.001), TC/high-density lipoprotein-cholesterol (HDL-C) ratio (β = -0.084, p < 0.01 and -0.096, p < 0.001), and triglycerides (TG) (women only; β = -0.053, p < 0.05). However, β cell function was not associated with HDL-C in men or women (β = -0.034 and 0.000, respectively, both p > 0.05) or the TG/HDL-C ratio (β = -0.035 and -0.013, respectively, both p > 0.05). β cell function was significantly worse in males than in females in all age groups, except in subjects aged > 70 years. Conclusions: Dyslipidemia is associated with dysfunction of pancreatic β cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males. Trial Registration Number: #TR-CCH-Chi CTR-CCH-00000361 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712458
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 84480349
- Full Text :
- https://doi.org/10.1186/1471-2458-12-634