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Carbohydrate-conjugated porphyrin dimers: Synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy
- Source :
-
Bioorganic & Medicinal Chemistry . Jan2013, Vol. 21 Issue 1, p153-165. 13p. - Publication Year :
- 2013
-
Abstract
- Abstract: We report the synthesis of bioconjugated zinc porphyrin dimers 1a–e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 84368286
- Full Text :
- https://doi.org/10.1016/j.bmc.2012.10.042