PESQUISA DE HEMOGLOBINA H INTRA-ERITROCITÁRIA EM PORTADORES DE ANEMIA MICROCÍTICA EM LABORATÓRIO DE REFERÊNCIA EM MARINGÁ-PR.

The hereditary anemias are among the most common genetic diseases and conditions include a group of variable complexity. The thalassemias are a heterogeneous group of hereditary diseases characterized by total or partial deficiency of the synthesis of alpha or beta globin, ranking respectively as alpha thalassemia and beta thalassemia. The severity of this disease is associated with the degree of impairment of expression of the alpha chain, and one of the four altered genes, characterizing asymptomatic patients or even incompatible with life. In this regard, we emphasize that the study objective is to determine the frequency of microcytic anemia caused by alpha thalassemia and also determine the prevalence of the condition in the population of Maringá - PR. We selected 89 samples from patients with microcytic anemia characterized of which were stained with brilliant cresyl blue for research Hemoglobin H (HbH) intraerythrocytic. The results showed that 2,2% of samples were from patients with thalassemia. We conclude that there is a need for further epidemiological studies to characterize popular site studied as well as use of quantitative methods for the classification of thalassemia and the importance of genetic counseling for thalassemia patients identified in the study. [ABSTRACT FROM AUTHOR]