Back to Search
Start Over
Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.
- Source :
-
Journal of Laryngology & Otology . Nov2012, Vol. 126 Issue 11, p1134-1137. 4p. - Publication Year :
- 2012
-
Abstract
- Objective:To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.Design:Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.Results:The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.Conclusion:Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00222151
- Volume :
- 126
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Laryngology & Otology
- Publication Type :
- Academic Journal
- Accession number :
- 84124828
- Full Text :
- https://doi.org/10.1017/S0022215112001995