Comparative evaluation of new carriers for controlled drug delivery based on Eudragit EPO/L100 interpolyelectrolyte complexes.

New interpolyelectrolyte complexes (IPECs) between oppositely charged Eudragit EPO and Eudragit L100 were investigated with a view to the development of oral controlled drug delivery systems (DDS). Structural features of the samples were evaluated by modulated-temperature differential scanning calorimetry (MTDSC). The results confirmed that all IPECs were chemically homogeneous and were characterized by only one glass-transition temperature. Evaluation of the diffusion-transport properties of the investigated IPECs revealed the basic mechanisms responsible for the controlled delivery of drugs with different physicochemical properties. The results showed that the synthesized IPECs have great potential to be used as pH-sensitive oral controlled DDS. [ABSTRACT FROM AUTHOR]