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Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams.
- Source :
-
Physics in Medicine & Biology . 12/7/2012, Vol. 57 Issue 23, pN457-N467. 11p. - Publication Year :
- 2012
-
Abstract
- This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of GNPs (on the order of 0.1 mg) within a 3 cm diameter plastic phantom. In particular, the performance of the current XFCT setup was improved remarkably (e.g., at least a factor of 3 reduction in XFCT scan time) using a tin-filtered polychromatic beam in comparison with a lead-filtered beam. The results of this study strongly suggest that the current benchtop XFCT configuration can be made practical with a few modifications such as the deployment of array detectors, while meeting realistic constraints on x-ray dose, scan time and image resolution for routine pre-clinical in vivo imaging with GNPs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319155
- Volume :
- 57
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Physics in Medicine & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 83883639
- Full Text :
- https://doi.org/10.1088/0031-9155/57/23/N457