More than one way to TRIM a capsid.

The article focuses on tripartite motif-containing protein 21 (TRIM21) which is found to degrade virion capsid. The author states that the TRIM21 binds the adenovirus capsid in the cytoplasm and triggers capsid degradation by the proteasome. He note that neutralizing antibodies are believed to block interaction of the virion with cognate cell surface receptors on susceptible target cells.