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A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agents
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2012, Vol. 22 Issue 24, p7418-7421. 4p. - Publication Year :
- 2012
-
Abstract
- Abstract: A series of dispiropyrrolothiazoles compounds were synthesized using 1,3-dipolar cycloaddition and were screened for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and INH resistant M. tuberculosis strains. Two of them were showing good activity with MIC of less than 1μM. Compound (5f) was found to be the most active with MIC of 0.210 and 8.312μM respectively. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 22
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 83710493
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.10.059